Early activation of PBMC and appearance of antiviral CD8+ cells influence the prognosis of SIV-induced disease in rhesus macaques
| Autor: | D Galbreath, Opendra Narayan, David M. Pinson, Larry Foresman, M C Zink, Robert J. Adams, H M McClure, S. V. Joag |
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| Rok vydání: | 1994 |
| Předmět: |
Time Factors
Simian Acquired Immunodeficiency Syndrome Disease CD8-Positive T-Lymphocytes Biology Lymphocyte Activation Virus Replication Peripheral blood mononuclear cell Lymphocyte Depletion Virus Predictive Value of Tests Animals Lymphocyte Count Early activation Cells Cultured General Veterinary T lymphocyte Prognosis Macaca mulatta Virology Peripheral blood Immunology Lymphocyte activation Simian Immunodeficiency Virus Animal Science and Zoology CD8 |
| Zdroj: | Journal of Medical Primatology. 23:108-116 |
| ISSN: | 0047-2565 |
| DOI: | 10.1111/j.1600-0684.1994.tb00110.x |
| Popis: | We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen-stimulated PBMC, while in phase 3, virus was recovered from mitogen-stimulated PBMC only after depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy. |
| Databáze: | OpenAIRE |
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