| Autor: |
Puja Sandbhor, Jayant Goda, Bhabani Mohanty, Poonam Gera, Sandhya Yadav, Godanjali Chekuri, Pradip Chaudhari, Shilpee Dutt, Rinti Banerjee |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Drug delivery and translational research. |
| ISSN: |
2190-3948 |
| Popis: |
Nanotechnology-based drug delivery platforms have shown great potential in overcoming the limitations of conventional therapy for glioblastoma (GBM). However, permeation across the blood-brain barrier (BBB), physiological complexity of the brain, and glioma targeting strategies cannot entirely meet the challenging requirements of distinctive therapeutic delivery stages. The objective of this research is to fabricate lipid nanoparticles (LNPs) for the co-delivery of paclitaxel (PTX) and miltefosine (HePc) a proapoptotic agent decorated with transferrin (Tf-PTX-LNPs) and investigate its anti-glioma activity both in vitro and in vivo orthotopic NOD/SCID GBM mouse model. The present study demonstrates the anti-glioma effect of the dual drug combination of PTX and proapoptotic HePc lipid-based transferrin receptor (TfR) targeted alternative delivery (direct nose to brain transportation) of the nanoparticulate system (Tf-PTX-LNPs, 364 ± 5 nm, -43 ± 9 mV) to overcome the O |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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