Magnesium ascorbyl phosphate vesicular carriers for topical delivery; preparation, in-vitro and ex-vivo evaluation, factorial optimization and clinical assessment in melasma patients
| Autor: | Soha M. Kandil, Iman I. Soliman, Heba M. Diab, Nermeen I. Bedair, Marwa H. Mahrous, Ebtsam M. Abdou |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Drug Carriers Dose-Response Relationship Drug Surface Properties Chemistry Pharmaceutical Neurocutaneous Syndromes Pharmaceutical Science Antineoplastic Agents General Medicine Ascorbic Acid Middle Aged Administration Cutaneous Melanosis Rats Drug Liberation Drug Stability Liposomes Animals Humans Female Gels |
| Zdroj: | Drug delivery. 29(1) |
| ISSN: | 1521-0464 |
| Popis: | Ascorbic acid (vitamin C) is an antioxidant that is widely used in cosmetics in skincare products. Due to the excessive low stability of ascorbic acid in cosmetic formulations, the stabilized ascorbic acid derivative, magnesium ascorbyl phosphate (MAP) was formulated as vesicular carriers; ethosomes and niosomes. The aim was to deliver MAP at the intended site of action, the skin, for sufficient time with enhanced permeation to get an effective response. Ethosomes were formulated using a full 3 |
| Databáze: | OpenAIRE |
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