Growth-differentiation factor-15 and functional outcome after acute ischemic stroke
| Autor: | Rosine Lahno, Katrin Wasser, Beatrice Haase, Klaus Gröschel, Mark Weber-Krüger, Joachim Seegers, Raoul Stahrenberg, Cord-Friedrich Niehaus, Dirk Vollmann, Sonja Schnaudigel, Rolf Wachter, Frank T. Edelmann, Janin Wohlfahrt |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty Growth Differentiation Factor 15 Neurology GDF-15 Clinical trial Ischemic stroke TIA Biomarker Outcome Clinical Neurology 030204 cardiovascular system & hematology Medicine & Public Health Neuroradiology Neurosciences Brain Ischemia Brain ischemia 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Prospective Studies 10. No inequality Prospective cohort study Stroke Aged Original Communication business.industry Recovery of Function Odds ratio Middle Aged medicine.disease Confidence interval Surgery Treatment Outcome Cohort Population study Female Neurology (clinical) business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology |
| ISSN: | 0340-5354 |
| DOI: | 10.1007/s00415-011-6379-0 |
| Popis: | Blood biomarkers may improve the performance in predicting early stroke outcome beyond well-established clinical factors. We investigated the value of growth-differentiation factor-15 (GDF-15) to predict functional outcome after 90 days in a prospectively collected patient cohort with symptoms of acute ischemic stroke. Two hundred eighty-one patients with symptoms of acute ischemic stroke were prospectively investigated. Serial blood samples for GDF-15 analysis were obtained after the admission of the patient, after 6 and 24 h. Primary outcome was the dichotomized modified ranking scale (MRS) 90 days after the initial clinical event. Within the final study population (264 patients, mean age 70.3 ± 12.7 years, 55.3% male), National Institutes of Health Stroke Scale (NIH-SS) [odds ratio (OR) 1.269, 95% confidence interval (CI) 1.141–1.412, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|