Reducing Human-Tsetse Contact Significantly Enhances the Efficacy of Sleeping Sickness Active Screening Campaigns: A Promising Result in the Context of Elimination
| Autor: | Mamadou Camara, Michael J. Lehane, Moise Kagbadouno, Vincent Jamonneau, Jean-Baptiste Rayaissé, Martin Bienvenu Somda, Moana Peylhard, Emilie Dama, J. Rouamba, Steve J. Torr, Oumou Camara, Bruno Bucheton, Fabrice Courtin, Ibrahima Sory Traoré, Mamadou Leno, Philippe Solano |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Veterinary medicine
lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Prevalence Context (language use) wa_395 wa_110 Environmental health wc_705 qx_600 medicine African trypanosomiasis qx_505 Mass screening Disease burden biology Transmission (medicine) lcsh:Public aspects of medicine Public Health Environmental and Occupational Health Tsetse fly Tropical disease lcsh:RA1-1270 medicine.disease biology.organism_classification Infectious Diseases qx_650 |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003727 (2015) |
| ISSN: | 1935-2735 |
| Popis: | Background\ud \ud Control of gambiense sleeping sickness, a neglected tropical disease targeted for elimination by 2020, relies mainly on mass screening of populations at risk and treatment of cases. This strategy is however challenged by the existence of undetected reservoirs of parasites that contribute to the maintenance of transmission. In this study, performed in the Boffa disease focus of Guinea, we evaluated the value of adding vector control to medical surveys and measured its impact on disease burden.\ud \ud Methods\ud \ud The focus was divided into two parts (screen and treat in the western part; screen and treat plus vector control in the eastern part) separated by the Rio Pongo river. Population census and baseline entomological data were collected from the entire focus at the beginning of the study and insecticide impregnated targets were deployed on the eastern bank only. Medical surveys were performed in both areas in 2012 and 2013.\ud \ud Findings\ud \ud In the vector control area, there was an 80% decrease in tsetse density, resulting in a significant decrease of human tsetse contacts, and a decrease of disease prevalence (from 0.3% to 0.1%; p=0.01), and an almost nil incidence of new infections (1%, p |
| Databáze: | OpenAIRE |
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