Differential expression of duplicated genes for prothymosin alpha during zebrafish development
| Autor: | Francesco Aniello, Annamaria Locascio, Daniela Liccardo, Sergio Minucci, Daniela Esposito, Aldo Donizetti, Rosanna del Gaudio, Diana Ferrara |
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| Přispěvatelé: | Donizetti, A, Liccardo, D, Esposito, D, DEL GAUDIO, R, Locascio, A, Ferrara, D, Minucci, Sergio, Aniello, F., Donizetti, Aldo, DEL GAUDIO, Rosanna, Minucci, S, Aniello, Francesco |
| Rok vydání: | 2008 |
| Předmět: |
Molecular Sequence Data
In situ hybridization Biology Prothymosin Alpha 03 medical and health sciences Gene duplication Animals Humans Protein Isoforms zebrafish embryo Amino Acid Sequence Protein Precursors Gene Zebrafish In Situ Hybridization Phylogeny pronephric duct 030304 developmental biology Genetics Regulation of gene expression 0303 health sciences endodermal pouches fungi 030302 biochemistry & molecular biology Embryogenesis ptma gene duplication Gene Expression Regulation Developmental Zebrafish Proteins central nervous system biology.organism_classification eye Embryonic stem cell Cell biology Thymosin placode Sequence Alignment Developmental Biology |
| Zdroj: | Developmental Dynamics. 237:1112-1118 |
| ISSN: | 1097-0177 1058-8388 |
| DOI: | 10.1002/dvdy.21492 |
| Popis: | We show that ptma, a single copy gene found in all organisms investigated so far, is duplicated in zebrafish. The two genes, ptmaa and ptmab, are individually controlled as indicated by their different expression patterns during embryonic development. Only the ptmab transcript is observed at 4 and 8 hpf of development in all embryonic cells, whereas both genes are expressed at later stages as revealed by in situ hybridization studies. In most cases, the two genes are expressed in the same territories, but only the ptmaa transcript was found in the trigeminal ganglion and in endodermal pouches. In the eye, at 72 hpf, the ptmaa and ptmab transcripts were found in amacrine cells, whereas only the ptmab transcript appeared in horizontal cells. The existence of two prothymosin genes indicates that their function in cell proliferation and differentiation is more complex in fishes than in mammals. Developmental Dynamics 237:1112–1118, 2008. © 2008 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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