Receptor activator of nuclear factor kappa B ligand serum and synovial fluid level. A comparative study between rheumatoid arthritis and osteoarthritis
| Autor: | Shimaa S. Ahmed, Abdou S. Ellabban, Ashraf M Osman, Shereen R. Kamel |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Knee Joint Immunology Enzyme-Linked Immunosorbent Assay Osteoarthritis Gastroenterology Severity of Illness Index Nuclear factor kappa b Arthritis Rheumatoid Young Adult Rheumatology Predictive Value of Tests Internal medicine Surveys and Questionnaires Synovial Fluid medicine Immunology and Allergy Synovial fluid Humans Receptor Pain Measurement biology business.industry Activator (genetics) RANK Ligand Middle Aged Osteoarthritis Knee medicine.disease Arthralgia Radiography RANKL Rheumatoid arthritis biology.protein Egypt Female business Biomarkers |
| Zdroj: | Rheumatology international. 32(6) |
| ISSN: | 1437-160X |
| Popis: | To assess the levels of receptor activator of NF-κB ligand (RANKL) in serum and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to correlate its levels with disease activity and severity. Serum and SF levels of RANKL were measured in 24 patients with RA (Group I) and 20 patients with OA (Group II); patients were selected according to the ACR criteria, and serum RANKL was measured in 13 healthy controls. All patients were subjected to full rheumatological assessment. In RA group, serum level of RANKL was significantly higher than control group (P = 0.01), but not correlated with disease activity and severity parameters apart from number of tender joints (P = 0.03). SF level of RANKL was significantly correlated with disease duration (P = 0.02), number of tender (P = 0.002) and swollen joints (P = 003), ESR (P = 0.01), CRP (P = 0.000), DAS-28 (P = 0.004), and SENS (P = 0.03). In patients with OA, serum level of RANKL was significantly higher than the control group (P |
| Databáze: | OpenAIRE |
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