Multidrug-Resistant Typhoid in Children: Presentation and Clinical Features
| Autor: | Badr J. Farooqui, Zulfiqar A Bhutta, Raza A. Razzaq, Shehla H. Naqvi |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Salmonella medicine.drug_class Antibiotics Chloramphenicol Resistance medicine.disease_cause Typhoid fever Internal medicine Ampicillin Trimethoprim Sulfamethoxazole Drug Combination Humans Medicine Blood culture Typhoid Fever Child Retrospective Studies Disseminated intravascular coagulation medicine.diagnostic_test business.industry Chloramphenicol Infant Drug Resistance Microbial Salmonella typhi medicine.disease Multiple drug resistance Infectious Diseases Child Preschool Immunology Female business Ampicillin Resistance medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 13:832-836 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Typhoid accounts for 8% of pediatric admissions to the Aga Khan University Hospital in Karachi, Pakistan. Over a 4-year period (1986-1989), 355 children had typhoid documented by culture of blood or bone marrow. Strains of Salmonella, resistant to ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole accounted for 20% of these cases. Compared with children infected by drug-susceptible strains of Salmonella, children with multiresistant infection were generally sicker at presentation and were more likely to be assessed as appearing "toxic" (P less than .001), as having disseminated intravascular coagulation (P less than .01), and as exhibiting hepatomegaly (P less than .01). The mortality was 4.2% among children with multiresistant infection and 1.4% among those infected with strains susceptible to ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole; the higher mortality in the former group was probably due to a longer duration of illness (P less than .05) and to ineffectual oral antimicrobial therapy before hospitalization. |
| Databáze: | OpenAIRE |
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