Maternal Serum Placental Protein-13 Levels in the Prediction of Pregnancies with Abnormal Invasive Placentation
| Autor: | Uğur Turhan, Banuhan Şahin, Buğra Şahin, Andrea Tinelli, Ismail Dag |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Singleton pregnancy medicine.medical_treatment Placenta Uterus Pregnancy Maternity and Midwifery Medicine Humans Prospective Studies Hysterectomy business.industry Obstetrics Cesarean Section Obstetrics and Gynecology Placentation Placental protein medicine.disease Pathophysiology medicine.anatomical_structure Case-Control Studies Pediatrics Perinatology and Child Health Gestation Female business |
| Zdroj: | Zeitschrift fur Geburtshilfe und Neonatologie. 225(3) |
| ISSN: | 1439-1651 |
| Popis: | Objective To evaluate whether placental protein-13 (PP-13) measured in the serum of pregnant women could predict abnormal invasive placentation (AIP) detected by color Doppler ultrasound (US) and magnetic resonance imaging scan in addition to the routine US scan during the third trimester. Materials and methods The prospective case-control study included patients subdivided in 2 groups: 42 pregnant women with a singleton pregnancy at 28–32 weeks of gestation with only suspected AIP, and 32 healthy pregnant women. The serum PP-13 levels were measured in both groups using an enzyme-linked immunosorbent assay (ELISA) method and statistically compared. The cases of AIP were confirmed by placental histopathological examination and/or the uterus removed by hysterectomy after elective caesarean section. Results Serum PP-13 levels of pregnant women with AIP were significantly higher (p Conclusion Maternal serum PP-13 may have a role in the pathophysiology of AIP owing to its high serum value in the AIP group. The maternal serum dosage of PP-13 levels could improve pregnancy management in those patients suspected of having AIP. |
| Databáze: | OpenAIRE |
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