Receptor‐Targeted Luminescent Silver Bionanoparticles

Autor:	Tessa Buckle, Marcel A. Verheijen, Patrick T. K. Chin, Arjan Barendregt, Marte van der Linden, Fijs W. B. van Leeuwen, Anton Bunschoten
Přispěvatelé:	Plasma & Materials Processing, Atomic scale processing
Rok vydání:	2016
Předmět:	Silver Nanoparticle Imaging agents Medicinal chemistry Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Bioinorganic chemistry Nanoclusters Inorganic Chemistry symbols.namesake Stokes shift medicine BioNanoTechnology Chemistry 021001 nanoscience & nanotechnology Human serum albumin 0104 chemical sciences Drug delivery symbols Biophysics Nanoparticles 0210 nano-technology Biological imaging Luminescence medicine.drug
Zdroj:	European Journal of Inorganic Chemistry, 2016(18), 3030-3035 European Journal of Inorganic Chemistry, 3030-3035 ISSUE=18;STARTPAGE=3030;ENDPAGE=3035;TITLE=European Journal of Inorganic Chemistry European Journal of Inorganic Chemistry, 18, 3030-3035. Wiley-VCH Verlag European Journal of Inorganic Chemistry 2016 (2016) 18
ISSN:	1099-0682 1434-1948
Popis:	Luminescent Ag nanoclusters (Ag-NC) provide the next generation in bionanoparticles, wherein the luminescence (650 nm) and large Stokes shift of these inorganic nanoclusters are favorable for biological imaging. By combining these characteristics with those of human serum albumin (HSA; a protein capable of binding multiple endo- and exogenous compounds), the Ag nanoclusters can be shielded from the environment and functionalized with (receptor) targeting moieties. Encapsulation of the 1.5 nm Ag nanoclusters by HSA resulted in a threefold increase in luminescence intensity and a twofold increase of the luminescence lifetime (1.7 vs. 3.6 µs). To exemplify the potential of this targeted concept, we functionalized HSA-Ag nanoparticles with chemokine receptor 4 (CXCR4) targeting peptides [Ac-TZ14011(CO2H)]. The resulting Ac-TZ14011-HSA-Ag nanoparticles demonstrated specific binding to CXCR4-overexpressing tumor cells. Upon exposure to (ambient) light, particle-functionalized tumor cells were killed. Combined, these experiments illustrate that HSA-Ag nanoparticles may have a potential in biological imaging and possibly even in targeted theranostic applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4f9e9a757a21ae814b81c35adc5a5f https://doi.org/10.1002/ejic.201501414 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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