The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal disease
| Autor: | Aylin Hande Gokce, Hafize Uzun, Remise Gelisgen, Feridun Suat Gökçe, Sinem Durmus, Ramila Hajiyeva, Feyzullah Ersoz |
|---|---|
| Přispěvatelé: | İÜC, Cerrahpaşa Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Gokce, Aylin Hande |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Medicine (General) Endogeny 030204 cardiovascular system & hematology Arginine Gastroenterology Hemorrhoids Nitric oxide Hemorroidas 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine R5-920 Enos Internal medicine Arginine/analogs & derivatives medicine Humans 030304 developmental biology 0303 health sciences biology business.industry Nitric oxide synthase Nitric Oxide Synthase Type III General Medicine medicine.disease biology.organism_classification Óxido nítrico sintase tipo III Pathophysiology Arginina/análogos & derivados chemistry Nitric oxide synthase type III biology.protein Óxido nítrico sintase Asymmetric dimethylarginine business Óxido nítrico |
| Zdroj: | Revista da Associação Médica Brasileira, Vol 66, Iss 8, Pp 1128-1133 (2020) Revista da Associação Médica Brasileira v.66 n.8 2020 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB Revista da Associação Médica Brasileira, Volume: 66, Issue: 8, Pages: 1128-1133, Published: 11 SEP 2020 |
| ISSN: | 1806-9282 |
| Popis: | SUMMARY AIM The aim of this study was to examine the roles of nitric oxide (NOx), endothelial nitric oxide synthetase (eNOS), and asymmetric dimethylarginine (ADMA), which is the major endogenous inhibitor of nitric oxide synthases (NOS), in the pathophysiology of hemorrhoidal disease. METHODS This study included 54 patients with grades 3 and 4 internal hemorrhoidal disease and 54 patients without the disease who attended the General Surgery Clinic. NOx, eNOS, and ADMA levels were measured with the Enzyme-Linked ImmunoSorbent Assay (ELISA) method. RESULTS The patients had higher NO and eNOS levels and lower ADMA levels than the control subjects (p |
| Databáze: | OpenAIRE |
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