Monitoring anticoagulant therapy with vitamin K antagonists in patients with antiphospholipid syndrome
| Autor: | Wolfgang Miesbach, Vanessa Tirneci, Adele Weber, Mecki Isert, Yvonne Weil, Eva Herrmann, Birgit Linnemann, Alexander Kasper, Gundolf Schüttfort, Edelgard Lindhoff-Last |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Vitamin K Vitamin k Gastroenterology Cohort Studies Antiphospholipid syndrome health services administration Internal medicine medicine Animals Humans Thromboplastin heterocyclic compounds In patient International Normalized Ratio cardiovascular diseases Blood Coagulation Aged Prothrombin time Systemic lupus erythematosus medicine.diagnostic_test business.industry fungi Anticoagulants Hematology General Medicine Middle Aged Antiphospholipid Syndrome medicine.disease Surgery Anticoagulant therapy Cohort Prothrombin Time Female Rabbits Drug Monitoring business Follow-Up Studies |
| Zdroj: | Annals of Hematology. 94:1291-1299 |
| ISSN: | 1432-0584 0939-5555 |
| Popis: | Because of the possible interference of antiphospholipid antibodies (APL) with the phospholipid component of thromboplastin reagents, concerns have been raised about the validity of international normalized ratio (INR) testing to monitor anticoagulant therapy with vitamin K antagonists in patients with antiphospholipid syndrome (APS). To investigate the reliability of the INR, we determined the INR using various prothrombin time (PT) assays and compared the results with those of a chromogenic factor X (CFX) assay. The study cohort consisted of 40 APS patients and 100 APL-negative patients who were on anticoagulant therapy for reasons other than APS. The agreement (i.e. the percentage of patients with a difference ≤0.5 INR units) between the PT-derived INR and CFX-derived INR equivalents was only moderate in both patient groups. The best agreement with CFX-derived INR equivalents was observed for the Thromborel S reagent in APS patients (69.1 %) and for Neoplastin Plus in APL-negative patients (72.0 %). Regarding the results for the point-of-care system CoaguChek XS, an agreement between the INR and the CFX-derived INR equivalent was less frequently observed in the APS patients (55.6 vs. 67.8 %; p = 0.050). When considering all 3058 pairs of INR tests within the international sensitivity index (ISI)-calibrated range of 1.5 to 4.5 s, we did not observe a higher variability of INR values in either the APS patient group or the subgroup of APS patients positive for lupus coagulants compared with the APL-negative controls. In conclusion, monitoring vitamin K antagonists (VKA) therapy with laboratory INR measurements seems to be suitable for the majority of APS patients. |
| Databáze: | OpenAIRE |
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