Keel bone fractures induce a depressive-like state in laying hens
| Autor: | Victoria Sandilands, Tom V. Smulders, Jane Eastham, Michael J. Toscano, Elena A. Armstrong, Jonathan Guy, Cristina Rufener, Timothy Boswell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Doublecortin Domain Proteins Sternum Neurogenesis lcsh:Medicine Physiology Gene Expression Hippocampal formation Adult neurogenesis Animal Welfare Hippocampus Article Avian Proteins 03 medical and health sciences Fractures Bone 0302 clinical medicine Limbic system Medicine Animals Chronic stress Animal Husbandry lcsh:Science Poultry Diseases Neurons Multidisciplinary Trauma Severity Indices 630 Agriculture business.industry Reproduction lcsh:R Neuropeptides Individual level Housing Animal 030104 developmental biology Biomarker (medicine) lcsh:Q Female Flock business Keel (bird anatomy) Stress and resilience Chickens Microtubule-Associated Proteins 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Scientific Reports Armstrong, E. A.; Rufener, C.; Toscano, M. J.; Eastham, J. E.; Guy, J. H.; Sandilands, V.; Boswell, T.; Smulders, T. V. (2020). Keel bone fractures induce a depressive-like state in laying hens. Scientific reports, 10(1), p. 3007. Springer Nature 10.1038/s41598-020-59940-1 Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020) |
| ISSN: | 2045-2322 |
| Popis: | In commercial flocks of laying hens, keel bone fractures (KBFs) are prevalent and associated with behavioural indicators of pain. However, whether their impact is severe enough to induce a depressive-like state of chronic stress is unknown. As chronic stress downregulates adult hippocampal neurogenesis (AHN) in mammals and birds, we employ this measure as a neural biomarker of subjective welfare state. Radiographs obtained longitudinally from Lohmann Brown laying hens housed in a commercial multi-tier aviary were used to score the severity of naturally-occurring KBFs between the ages of 21–62 weeks. Individual birds’ transitions between aviary zones were also recorded. Focal hens with severe KBFs at 3–4 weeks prior to sampling (n = 15) had lower densities of immature doublecortin-positive (DCX+) multipolar and bipolar neurons in the hippocampal formation than focal hens with minimal fractures (n = 9). KBF severity scores at this time also negatively predicted DCX+ cell numbers on an individual level, while hens that acquired fractures earlier in their lives had fewer DCX+ neurons in the caudal hippocampal formation. Activity levels 3–4 weeks prior to sampling were not associated with AHN. KBFs thus lead to a negative affective state lasting at least 3–4 weeks, and management steps to reduce their occurrence are likely to have significant welfare benefits. |
| Databáze: | OpenAIRE |
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