Patterns of pituitary dysfunction three months or more after traumatic brain injury
| Autor: | Nassar Taha Yaseen, Abbas Ali Mansour, Fateh A Al-Khaqani |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Univariate analysis
Pediatrics medicine.medical_specialty business.industry Traumatic brain injury traumatic brain injury 030209 endocrinology & metabolism Hypopituitarism medicine.disease Growth hormone deficiency Head trauma 03 medical and health sciences 0302 clinical medicine hypopituitarism head trauma medicine Medicine Original Article Pituitary dysfunction business Road traffic 030217 neurology & neurosurgery |
| Zdroj: | Avicenna Journal of Medicine Avicenna Journal of Medicine, Vol 8, Iss 04, Pp 125-132 (2018) |
| ISSN: | 2249-4464 2231-0770 |
| DOI: | 10.4103/ajm.ajm_2_18 |
| Popis: | Purpose: Chronic posttraumatic brain injury (TBI) pituitary dysfunction is not a newly discovered subject, it has been reported more frequently, probably due to increasing chances of exposure to its causes, mainly the road traffic accidents, sport-related injuries, falls, and injuries during wars. This study aims to estimate the frequency of pituitary dysfunction 3 months or more after head trauma and the patterns of hormonal deficiencies. Methods: A cross-sectional study was conducted between January 2016 and August 2017. Participants were patients having a history of moderate-to-severe TBI at least 3 months before enrolment. Pituitary function test was done for all patients to determine the frequency of pituitary dysfunction, the number of axes deficiencies, and which hormone is mostly affected. Statistical Package for the Social Sciences (SPSS) version 23.0 was used for univariate analysis, P < 0.05 was considered statistically significant. Results: Out of the 28 patients involved in this study, 17 (61%) had pituitary dysfunction, while 11 (39%) had not. Single hormonal defect was the most prevalent abnormality in 12 (43%), and the most affected hormone was the growth hormone (GH) in 14 patients (50%), followed by gonadal axis, thyroid stimulating hormone, and finally adrenocorticotropic hormone (ACTH), 6 (21%), 3 (11%), and 1 (4%), respectively. Conclusion: TBI pituitary dysfunction is more prevalent than was predicted in the population studied, single hormonal defect was found to be the most prevalent abnormality, being the GH is the most affected axis, and the ACTH seems to be the least. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|