Circulating adiponectin levels and systemic lupus erythematosus: a two-sample Mendelian randomization study
| Autor: | Hai-Feng Pan, De-Guang Wang, Qian Wu, Xue-Rong Wang, Peng Wang, Zhongle Cheng, Yi-Lin Dan |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Single-nucleotide polymorphism Genome-wide association study Polymorphism Single Nucleotide Risk Assessment Gastroenterology 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine Mendelian randomization Humans Lupus Erythematosus Systemic Medicine Pharmacology (medical) Two sample Correlation of Data 030203 arthritis & rheumatology Adiponectin business.industry Causal effect Mendelian Randomization Analysis Odds ratio 030104 developmental biology business Genome-Wide Association Study |
| Zdroj: | Rheumatology. 60:940-946 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objectives Several studies have reported increased serum/plasma adiponectin levels in SLE patients. This study was performed to estimate the causal effects of circulating adiponectin levels on SLE. Methods We selected nine independent single-nucleotide polymorphisms that were associated with circulating adiponectin levels (P Results The results of inverse-variance weighted methods showed no significantly causal associations of genetically predicted circulating adiponectin levels and the risk for SLE, with an odds ratio (OR) of 1.38 (95% CI 0.91, 1.35; P = 0.130). MR-Egger [OR 1.62 (95% CI 0.85, 1.54), P = 0.195], weighted median [OR 1.37 (95% CI 0.82, 1.35), P = 0.235) and weighted mode methods [OR 1.39 (95% CI 0.86, 1.38), P = 0.219] also supported no significant associations of circulating adiponectin levels and the risk for SLE. Furthermore, MR analyses in using SLE-associated single-nucleotide polymorphisms as an instrumental variable showed no associations of genetically predicted risk of SLE with circulating adiponectin levels. Conclusion Our study did not find evidence for a causal relationship between circulating adiponectin levels and the risk of SLE or of a causal effect of SLE on circulating adiponectin levels. |
| Databáze: | OpenAIRE |
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