Antimetabolites produced by microorganisms. XII. (S)-alanyl-3-(.ALPHA.-(S)-chloro-3-(S)-hydroxy-2-oxo-3-azetidinylmethyl)-(S)-alanine, a new .BETA.-lactam containing natural product
| Autor: | Thomas C. Demny, Florence Weiss, Arthur Stempel, David L. Pruess, Thomas H. Williams, James P. Scannell, Martha Kellett, Helen A. Ax, John F. Blount |
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| Rok vydání: | 1975 |
| Předmět: |
Serratia
Stereochemistry Glutamine Microorganism Alpha (ethology) Beta-lactam chemistry.chemical_compound Bacillus cereus Drug Discovery Escherichia coli Pharmacology Alanine Natural product biology Chemistry Azetines Dipeptides biology.organism_classification Streptomyces Anti-Bacterial Agents Klebsiella pneumoniae Chemically defined medium Crystallography Azetidines Growth inhibition Bacteria Bacillus subtilis |
| Zdroj: | The Journal of Antibiotics. 28:1-6 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.28.1 |
| Popis: | (S)-Alanyl-3-[alpha-(S)-chloro-3-(S)-hydroxy-2-oxo-3-azetidinylmethyl]-(S)-alanine was isolated from a fermentation broth of an unidentified Streptomyces species 372 A. The structure was determined by single crystal X-ray diffraction analysis. The substance inhibits the growth of several strains of gram-positive and gram-negative bacteria in a chemically defined medium but growth inhibition is relieved by addition of L-glutamine to the medium. |
| Databáze: | OpenAIRE |
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