CDK2 positively regulates aerobic glycolysis by suppressing SIRT5 in gastric cancer
Autor: | Qiang Xiao, Dongyi Xie, Kun Wu, Weiyuan Wei, Zhenyong Tang, Lei Li, Yuntian Tang |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
CDK2 Cancer Research Cell CDK2/SIRT5 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Cell Line Tumor SIRT5 medicine Gene silencing Humans Sirtuins Genetics Genomics and Proteomics Cell Proliferation Cell growth Kinase business.industry gastric cancer Cell Cycle Cyclin-Dependent Kinase 2 Cancer General Medicine Original Articles Cell cycle glycolysis medicine.disease Up-Regulation Survival Rate 030104 developmental biology medicine.anatomical_structure Oncology Anaerobic glycolysis 030220 oncology & carcinogenesis Cancer cell Cancer research Original Article business DNA Damage |
Zdroj: | Cancer Science |
ISSN: | 1349-7006 1347-9032 |
Popis: | Although significant progress has been made in the diagnosis and treatment of gastric cancer, the overall survival rate of the disease remains unchanged at approximately 20%-25%. Thus, there is an urgent need for a better understanding of the molecular biology aspects of the disease in the hope of discovering novel diagnosis and treatment strategies. Recent years have witnessed decisive roles of aberrant cancer cell metabolism in the maintenance of malignant hallmarks of cancers, and cancer cell metabolism has been regarded as a novel target for the treatment of cancer. CDK2, a cell cycle-dependent kinase that usually regulates cell cycle progression and the DNA damage response, is reported to be upregulated in many cancers. However, little is known about its role in cancer cell metabolism. In the present study, we showed that silencing CDK2 inhibited the aerobic glycolytic capacity of gastric cancer cell lines. Mechanism explorations showed that silencing CDK2 increased expression of the SIRT5 tumor suppressor. In addition, the physiological roles of SIRT5 in the regulation of proliferation and glycolysis were studied in gastric cancer cells. Taken together, the present study uncovered novel roles of the CDK2/SIRT5 axis in gastric cancer and suggests future studies concerning gastric cancer cell metabolism. |
Databáze: | OpenAIRE |
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