Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal blood-brain barrier permeability
| Autor: | Joel T. Park, Christine J. Harling-Berg, Helen F. Cserr, M. DePasquale, Paul M. Knopf |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Anterior Chamber Immunology Blood–brain barrier Antibodies Immunoglobulin G Rats Sprague-Dawley Immune system Cerebrospinal fluid Albumins Internal medicine medicine Animals Immunology and Allergy Complement Activation biology Albumin Antibody titer Rats Immunoglobulin Isotypes Titer Endocrinology medicine.anatomical_structure Neurology Blood-Brain Barrier Antibody Formation biology.protein Immunization Neurology (clinical) Antibody |
| Zdroj: | Journal of Neuroimmunology. 41:195-202 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/0165-5728(92)90070-2 |
| Popis: | Cerebrospinal fluid (CSF) and serum antibody responses to albumin administered into CSF or muscle have been compared with respect to titer, isotype profile and complement-fixing activity in a rat model with normal brain barrier function. CSF/serum titer ratios and the ratio of IgG subclasses, IgG1/IgG2, were both elevated following CSF immunization. In contrast, there was no difference in complement-fixing activity between antibodies elicited by the two routes of immunization. It is suggested that intrathecal antibody synthesis accounts for the elevated CSF antibody titers in CSF-immunized rats, providing the first example of central nervous system antibody synthesis in an animal with normal brain barrier permeability. |
| Databáze: | OpenAIRE |
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