Endoscopic observations as a tool to define underlying pathology in kidney stone formers
| Autor: | Dorte Ravnsmed Christensen, Helene Ulrich Jung, Palle Jørn Sloth Osther, Kim Hovgaard Andreassen, Maria Sloth Pless, James C. Williams, Susanne Sloth Osther |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nephrology
Adult Male Pathology medicine.medical_specialty Urology Urinary system 030232 urology & nephrology Total population Ureterorenoscopy Micro-computerized tomography 03 medical and health sciences Kidney Calculi Young Adult 0302 clinical medicine Papillae Internal medicine medicine Ureteroscopy Humans Prospective Studies Randall’s plaque Aged Aged 80 and over Renal stone medicine.diagnostic_test business.industry Middle Aged medicine.disease Endoscopy 030220 oncology & carcinogenesis Kidney calculi Kidney stones Original Article Female business |
| Zdroj: | World Journal of Urology Pless, M S, Williams, J C, Andreassen, K H, Jung, H U, Osther, S S, Christensen, D R & Osther, P J S 2019, ' Endoscopic observations as a tool to define underlying pathology in kidney stone formers ', World Journal of Urology, vol. 37, no. 10, pp. 2207-2215 . https://doi.org/10.1007/s00345-018-02616-3 |
| ISSN: | 1433-8726 0724-4983 |
| DOI: | 10.1007/s00345-018-02616-3 |
| Popis: | Purpose: Advancements in endoscopy offer the possibility of inspection of intrarenal anatomy and pathology. The aim of the study was to evaluate renal papillary appearance in kidney stone formers and to correlate papillary findings with stone type and patient metabolic data. Materials and methods: A consecutive cohort of 46 kidney stone formers undergoing retrograde intrarenal surgery was enrolled. During surgery, renal papillae were characterized in the domains of ductal Plugging (DP), surface Pitting, Loss of papillary contour, and Amount of Randall’s plaque (RP, PPLA scoring). Stone material was analyzed using micro-CT and infrared spectroscopy, and blood and urine were collected for metabolic evaluation. Results: In all patients, renal papillae had changes in at least one of the domains of the PPLA score. Examining the total population, it was evident that patients with predominantly plugging (DP > 0) all had very low RP scores. There were no significant trends between mean PPLA scores and urinary analytes for the total group. Conclusion: Efforts to prevent renal stone formation have so far been insufficient in majority of patients. Digital endoscopy reveals that kidney stone formers have different and distinct papillary morphologies that seem to be linked to specific stone-forming pathways. Since renal papillary abnormalities may be easily identified during endoscopy, this may in the future prove to be an important method for tailoring prevention strategies in kidney stone patients. |
| Databáze: | OpenAIRE |
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