Use of transvaginal ultrasonography to monitor the effects of tamoxifen on uterine leiomyoma size and ovarian cyst formation
| Autor: | Lisa Barrie Schwartz, Lila E. Nachtigall, Jon R. Snyder, Steven R. Goldstein, Camille Horan, Nicole Rutkowski |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Breast Neoplasms Endosonography Endometrium Breast cancer medicine Humans Radiology Nuclear Medicine and imaging Uterine Neoplasm Mastectomy Aged Gynecology Uterine leiomyoma Ovarian cyst Leiomyoma Radiological and Ultrasound Technology business.industry Estrogen Antagonists Myoma Middle Aged medicine.disease Antiestrogen female genital diseases and pregnancy complications Postmenopause body regions Ovarian Cysts Tamoxifen Uterine Neoplasms Vagina Disease Progression Female business Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Ultrasound in Medicine. 17:699-703 |
| ISSN: | 0278-4297 |
| DOI: | 10.7863/jum.1998.17.11.699 |
| Popis: | To evaluate the effects of tamoxifen on leiomyomas and ovarian cysts in postmenopausal breast cancer patients, uterine and leiomyoma volumes were monitored sonographically in 17 postmenopausal women receiving postoperative tamoxifen for breast cancer; patients were examined twice with a mean of 1.18 +/- 0.17 years between examinations. The mean increase in leiomyoma volume was 1.26 +/- 0.73 cm3. The mean myoma volume was significantly larger at follow-up evaluation than at initial ultrasonography (5.75 +/- 1.09 cm3 versus 4.36 +/- 0.817 cm3, respectively; Wilcoxon signed rank test, P = 0.0218). Six women developed new leiomyomas. Of the 21 leiomyomas initially detected, 13 increased, six decreased, and two were unchanged in volume. The mean increase in uterine volume was 17.45 +/- 8.49 cm3. Three patients had simple ovarian cysts at initial ultrasonographic examination, two of which remained unchanged in size, and the third resolved. Two patients had newly developed simple ovarian cysts. The increase in uterine and leiomyoma volumes with the development of new leiomyomas and the persistence or development of ovarian cysts in some patients support the existence of agonistic tamoxifen effects. Serial measurements of uterine and leiomyoma volumes and surveillance for ovarian cysts is recommended for tamoxifen users. |
| Databáze: | OpenAIRE |
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