Amlodipine besylate impairs the morphology of bone marrow in adult male wistar rats
| Autor: | OK Ghazali, GO Omotoso, LB Ayantunji, AA Adelaja |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Adult male business.industry medicine.drug_class Treatment regimen Calcium channel blocker Pharmacology medicine.disease Angina medicine.anatomical_structure Endocrinology Oral administration Internal medicine Medicine Pediatrics Perinatology and Child Health Amlodipine Bone marrow business Physiological saline medicine.drug |
| Zdroj: | Anatomy Journal of Africa. 6:867-872 |
| ISSN: | 2305-9478 2226-6054 |
| DOI: | 10.4314/aja.v6i1.160445 |
| Popis: | Amlodipine is a long-acting calcium channel blocker used in the treatment of hypertension and angina. In adult man, the treatment regimen is 5 or 10 mg daily. This study evaluated the effects of prolonged oral administration of Amlodipine Besylate on the morphology of bone marrow in adult male Wistar rats. Sixteen rats (140 - 190 g) comprising of four groups were employed in the study. Rats of Control Group I received physiological saline orally while rats of Experimental Groups II - IV received oral administrations of 5, 10 and 15 mg/kg bodyweight of Amlodipine Besylate respectively for nine weeks. Histo-pathological examinations of the bone marrow showed normal cytoarchitecture of erythrocytes and leukocytes in rats of Control Group I. However, dose-dependent degeneration and lyses of erythrocytes and leukocytes were observed in amlodipine-treated rats. In conclusion, impaired morphology of the bone marrow were observed in amlodipine-treated adult male Wistar ratsKey words: Amlodipine Besylate, bone marrow, morphology, rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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