Anti‐fibrotic activity of Euglena gracilis and paramylon in a mouse model of non‐alcoholic steatohepatitis
| Autor: | Yoshihisa Nakano, Kengo Suzuki, Chikara Yoshida, Ayaka Nakashima, Ryota Sugimoto, Yuka Shirakata, Taishi Hashiguchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Euglena gracilis ved/biology.organism_classification_rank.species Pharmacology Euglena 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fibrosis Paramylon medicine Sirius Red Original Research biology Chemistry ved/biology microalgae Fatty liver fibrosis NASH biology.organism_classification medicine.disease digestive system diseases 030104 developmental biology 030211 gastroenterology & hepatology Farnesoid X receptor Steatohepatitis Food Science |
| Zdroj: | Food Science & Nutrition Food Science & Nutrition, 7(1):139-147 |
| ISSN: | 2048-7177 |
| Popis: | Progression to non‐alcoholic steatohepatitis (NASH) manifests as hepatitis, fibrosis, and sometimes carcinoma, resulting in liver failure. Various clinical trials have indicated that several pharmacological agents, including angiotensin II receptor blockers (ARBs) or farnesoid X receptor (FXR) agonists, are effective in NASH treatment. In addition, functional foods are expected to be important alternatives for treating or preventing NASH. Recently, focus has been directed toward microalgae as dietary supplements, mainly for lifestyle‐related diseases, because they contain various nutrients and functional ingredients. Specifically, a unicellular microalga Euglena gracilis stores a unique β‐1,3‐glucan particle called paramylon that stimulates the immune system. In this study, we evaluated the effects of Euglena and paramylon on NASH in Stelic Animal Model (STAM) mice using Sirius red staining and confirmed that oral administration of Euglena or paramylon inhibits the process of liver fibrosis. Moreover, compared with controls, paramylon decreased non‐alcoholic fatty liver disease (NAFLD) activity scores related to inflammation. These results indicate that the oral administration of Euglena and paramylon inhibits fibrosis and ameliorates NASH. |
| Databáze: | OpenAIRE |
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