Simultaneous Single-Particle Tracking and Dynamic pH Sensing Reveal Lysosome-Targetable Mesoporous Silica Nanoparticle Pathways
| Autor: | Bi-Chang Chen, Peilin Chen, Chung-Yuan Mou, Feby Wijaya Pratiwi, Si Han Wu, Rong Lin Zhang |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Surface Properties Nanoparticle 02 engineering and technology Endocytosis 03 medical and health sciences Lysosome medicine Tumor Cells Cultured Humans General Materials Science Particle Size 030304 developmental biology 0303 health sciences Mesoporous silica Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Silicon Dioxide medicine.anatomical_structure Targeted drug delivery Single-particle tracking Ph sensing Biophysics Nanoparticles 0210 nano-technology Lysosomes Porosity Intracellular HeLa Cells |
| Zdroj: | ACS applied materialsinterfaces. 12(38) |
| ISSN: | 1944-8252 |
| Popis: | Nanoparticle (NP)-based targeted drug delivery is intended to transport therapeutically active molecules to specific cells and particular intracellular compartments. However, there is limited knowledge regarding the complete route of NPs in this targeting scenario. In this study, simultaneously performing motion and dynamic pH sensing using single-particle tracking (SPT) leads to an alternative method of gaining insights into the mesoporous silica nanoparticle's (MSN) journey in targeting lysosome. Two different pH-sensitive dyes and a reference dye are incorporated into mesoporous silica nanoparticles (MSNs) |
| Databáze: | OpenAIRE |
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