Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: dose-finding study with no concomitant use of hypnotic agent

Autor:	Satoru Suzuki, Yoshihiro Kaneko, Ryu Horikoshi, Yoshihiko Numata, Shin-Ichi Niwa, Yoshinori Watanabe, Hirobumi Mashiko, Hisashi Kumashiro
Rok vydání:	1999
Předmět:	Drug Adult Male Personality Inventory media_common.quotation_subject Pharmacology Drug Administration Schedule law.invention Dose finding Randomized controlled trial law Sleep Initiation and Maintenance Disorders medicine Humans Depression (differential diagnoses) media_common Depressive Disorder Dose-Response Relationship Drug business.industry General Neuroscience Trazodone General Medicine Middle Aged Sleep in non-human animals Psychiatry and Mental health Before Bedtime Treatment Outcome Neurology Anesthesia Concomitant Antidepressive Agents Second-Generation Female Neurology (clinical) business medicine.drug
Zdroj:	Psychiatry and clinical neurosciences. 53(2)
ISSN:	1323-1316
Popis:	This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3ef8ffc29c8909218bc1d61d6bec18 https://pubmed.ncbi.nlm.nih.gov/10459686 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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