Thyroid uptake of MIBG in Sipple's syndrome
| Autor: | Pierre Jallet, J. C. Bigorgne, J. J. Lejeune, R. Perdrisot, Vincent Rohmer |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Mibg uptake Scintigraphy Iodine Radioisotopes medicine Humans Radiology Nuclear Medicine and imaging Thyroid Neoplasms Radionuclide Imaging Aged Thyroid uptake medicine.diagnostic_test Iodobenzenes business.industry Carcinoma Multiple Endocrine Neoplasia Thyroid General Medicine Middle Aged medicine.disease 3-Iodobenzylguanidine medicine.anatomical_structure Medullary carcinoma APUD cell Female MULTIPLE ENDOCRINE NEOPLASIA TYPE II Sipple's syndrome business |
| Zdroj: | European Journal of Nuclear Medicine. 14 |
| ISSN: | 1619-7089 0340-6997 |
| DOI: | 10.1007/bf00252616 |
| Popis: | The use of the adrenomedullary tracer metaiodobenzylguanidine (MIBG) in the localization of medullary carcinoma of the thyroid (MCT) is based on the embryologic relationship of the APUD cell series. The authors report the results obtained in six patients with MCT: two had Sipple's syndrome and four sporadic forms of the disease. MIBG uptake by the CMT was observed in both cases of Sipple's syndrome and in only one of the other cases. Scintigraphic detection seems to depend on the clinical features, the size of the tumour and also on the part played by its secretory function. MCT would thus appear to be more frequently visualized by MIBG in cases of Sipple's syndrome than in sporadic cases. The procedure therefore seems useful in the diagnosis, follow up and even in the treatment of MCT. |
| Databáze: | OpenAIRE |
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