Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma
| Autor: | Peeter Karihtala, Heikki Huhta, Kirsi-Maria Haapasaari, Juha Saarnio, Petri Lehenkari, Ville Lindholm, Joonas H. Kauppila, Olli Helminen, Tuomo J. Karttunen, Joni Leppänen, Joel Isohookana |
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| Rok vydání: | 2019 |
| Předmět: |
Male
endocrine system diseases extracellular matrix Endocrinology Diabetes and Metabolism pancreatic cancer Kaplan-Meier Estimate Extracellular matrix 03 medical and health sciences 0302 clinical medicine Endocrinology Breast cancer Stroma fibronectin Pancreatic cancer Biomarkers Tumor Internal Medicine medicine Carcinoma Humans Pancreas Aged Hepatology biology Chemistry Tenascin C tenascin C Tenascin Original Articles Middle Aged Prognosis medicine.disease Immunohistochemistry digestive system diseases Fibronectins Pancreatic Neoplasms Fibronectin 030220 oncology & carcinogenesis embryonic structures ComputingMethodologies_DOCUMENTANDTEXTPROCESSING biology.protein Cancer research tumor-stroma ratio Female 030211 gastroenterology & hepatology Carcinoma Pancreatic Ductal |
| Zdroj: | Pancreas |
| ISSN: | 1536-4828 0885-3177 |
| DOI: | 10.1097/mpa.0000000000001195 |
| Popis: | Supplemental digital content is available in the text. Objectives Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma with increased expression of tenascin C and fibronectin. Their role and tumor-stroma ratio in PDAC are not well known. The aim of this study was to evaluate tenascin C and fibronectin expression and tumor-stroma ratio and their prognostic relevance in PDAC. Methods Ninety-five resected PDACs were immunohistochemically stained for tenascin C and fibronectin, and the expression was separately assessed in tumor bulk and front. Tumor-stroma ratio was determined with sections stained with hematoxylin-eosin. Results Tenascin C and fibronectin were abundantly expressed in the stroma of PDAC, but absent in adjacent normal pancreatic tissue. Fibronectin expression of the bulk was associated with high T class (P = 0.045). In the main analysis, tenascin C and fibronectin expression and tumor-stroma ratio were not associated with patient survival. In a subgroup analysis of early-stage PDAC (T1–T2 tumors), high tenascin C expression in the tumor bulk was associated with poor prognosis (hazard ratio, 8.23; 95% confidence interval, 2.71–24.96). Conclusions Tenascin C and fibronectin are abundantly expressed in PDAC, but they seem to have no major association with patient survival. However, in early-stage PDAC, tenascin C expression of the tumor bulk may have prognostic impact. Tumor-stroma ratio has no prognostic value in PDAC. |
| Databáze: | OpenAIRE |
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