Impact of severe diabetic kidney disease on the clinical outcome of autologous cell therapy in people with diabetes and critical limb ischaemia

Autor: Edward B. Jude, Jelena Skibova, Andrea Němcová, Vladimíra Fejfarová, Jitka Hazdrová, Jaroslav Chlupac, Alexandra Jirkovská, Michal Dubský, Karol Sutoris, Robert Bém
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Critical Illness
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Cell- and Tissue-Based Therapy
030209 endocrinology & metabolism
Revascularization
Severity of Illness Index
Transplantation
Autologous
Gastroenterology
Amputation
Surgical
Cell therapy
03 medical and health sciences
0302 clinical medicine
Endocrinology
Ischemia
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Diabetic Nephropathies
030212 general & internal medicine
Aged
Czech Republic
Retrospective Studies
Foot
business.industry
Hazard ratio
Case-control study
Retrospective cohort study
Middle Aged
Limb Salvage
medicine.disease
Diabetic Foot
Transplantation
Treatment Outcome
Case-Control Studies
Female
business
Vascular Surgical Procedures
Follow-Up Studies
Kidney disease
Zdroj: Diabetic Medicine. 36:1133-1140
ISSN: 1464-5491
0742-3071
Popis: AIM To assess the impact of autologous cell therapy on critical limb ischaemia in people with diabetes and diabetic kidney disease. METHODS A total of 59 people with diabetes (type 1 or type 2) and critical limb ischaemia, persisting after standard revascularization, were treated with cell therapy in our foot clinic over 7 years; this group comprised 17 people with and 42 without severe diabetic kidney disease. The control group had the same inclusion criteria, but was treated conservatively and comprised 21 people with and 23 without severe diabetic kidney disease. Severe diabetic kidney disease was defined as chronic kidney disease stages 4-5 (GFR
Databáze: OpenAIRE
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