The role of cathepsin B in autophagy during obesity: A systematic review
| Autor: | Thais Fenz Araujo, Kaio Fernando Vitzel, Vagner R. R. Silva, André V. Cordeiro, Diogo Antonio Alves de Vasconcelos |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Autophagy food and beverages Adipokine General Medicine White adipose tissue Biology medicine.disease General Biochemistry Genetics and Molecular Biology Cathepsin B Energy homeostasis Proinflammatory cytokine Cell biology 03 medical and health sciences 030104 developmental biology Diabetes mellitus medicine Animals Humans Obesity General Pharmacology Toxicology and Pharmaceutics Adipocyte hypertrophy |
| Zdroj: | Life Sciences. 209:274-281 |
| ISSN: | 0024-3205 |
| Popis: | White adipose tissue (WAT) regulates energy homeostasis by releasing adipokines and modulating cell maintenance. Nutrient excess affects adipocyte hypertrophy directly in WAT by increasing excessively the activity of autophagy systems, generating proinflammatory markers and increasing infiltration of macrophages, causing metabolic diseases such as obesity and diabetes. Evidences suggest that cathepsin B (CTSB), a papain-like cysteine peptidase protein, can modulate autophagy processes in adipocytes. This review will focus on the role of CTSB in autophagy under conditions of obesity. |
| Databáze: | OpenAIRE |
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