Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists

Autor:	R. J. Lynch, Guixiang Zhang, Nigel J. Liverton, Robert J. Gould, Remy David C, Donna J. Armstrong, David A. Claremon, John J. Baldvin
Rok vydání:	1999
Předmět:	Fibrinogen receptor Stereochemistry Clinical Biochemistry Pharmaceutical Science Platelet Glycoprotein GPIIb-IIIa Complex In Vitro Techniques Fibrinogen Biochemistry Chemical synthesis Structure-Activity Relationship Drug Discovery medicine Humans Molecular Biology Bicyclic molecule Chemistry Organic Chemistry Biological activity In vitro Glycoprotein IIb/IIIa inhibitors Quinazolines Molecular Medicine Platelet aggregation inhibitor Platelet Aggregation Inhibitors medicine.drug
Zdroj:	Bioorganicmedicinal chemistry letters. 8(5)
ISSN:	0960-894X
Popis:	The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of these structures as central templates for nonpeptide RGD mimics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d34e68fa88e1f133cca3c18e3ca6dd1 https://pubmed.ncbi.nlm.nih.gov/9871603 Zobrazit plný text záznamu Full Text from ScienceDirect