Wireless, battery-free and wearable device for electrically controlled drug delivery: sodium salicylate released from bilayer polypyrrole by near-field communication on smartphone
| Autor: | Zhaoyang Liu, Xin Li, Yanli Lu, Qingjun Liu, Zetao Chen, Jinglong Liu, Gang Xu, Lihang Zhu, Chen Cheng |
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| Rok vydání: | 2020 |
| Předmět: |
Paper
Drug Battery (electricity) Materials science Polymers Sodium Salicylate media_common.quotation_subject Biomedical Engineering Wearable computer 02 engineering and technology Polypyrrole 01 natural sciences Near field communication Wearable Electronic Devices chemistry.chemical_compound Drug Delivery Systems Electricity Pyrroles Electrodes Molecular Biology media_common Transdermal 010401 analytical chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences ComputingMethodologies_PATTERNRECOGNITION chemistry visual_art Drug delivery Electronic component visual_art.visual_art_medium Smartphone 0210 nano-technology Wireless Technology Biomedical engineering |
| Zdroj: | Biomedical Microdevices. 22 |
| ISSN: | 1572-8781 1387-2176 |
| Popis: | Compared with traditional drug delivery methods, transdermal drug delivery has many advantages in avoiding the side effects in gastrointestinal tract, reducing the fluctuations in drug concentration, and improving patients' compliance. Among them, electrically controlled drug delivery is a promising solution. This work presents a wireless, battery-free and wearable device with electrically controlled drug delivery capability. The electronic component of the device is a flexible circuit board with a temperature sensor and a near-field communication module. With the help of smartphone, the device could wirelessly obtain energy and implement data transmission. The drug delivery component is a paper-based electrode modified with polypyrrole, in which non-steroidal anti-inflammatory drug sodium salicylate was encapsulated. The applied potential for electrically controlled drug delivery was more negative than -0.6 V. The drug release dose and release rates could be controlled by applying potentials with different amplitudes and durations through this device. It provided a minimalized wearable transdermal drug delivery platform for monitoring diseases such as gout. This wearable device shows promising potential in develop closed-loop drug delivery and monitoring systems for the treatment of various diseases. |
| Databáze: | OpenAIRE |
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