Conservative therapy for chalazia: is it really effective?

Autor: Chen Wei, Albert Y. Wu, James H. Oestreicher, John T. Harvey, Kellie N Gergoudis, Kalla A Gervasio
Rok vydání: 2018
Předmět:
Male
Time Factors
medicine.medical_treatment
Conservative Treatment
Gastroenterology
Dexamethasone
law.invention
Ointments
0302 clinical medicine
Randomized controlled trial
law
Tobramycin
Medicine
Prospective Studies
030212 general & internal medicine
Aged
80 and over
education.field_of_study
General Medicine
Middle Aged
Curettage
Anti-Bacterial Agents
Tobramycin
Dexamethasone
Treatment Outcome
Chalazion
Population study
Drug Therapy
Combination
Female
medicine.drug
Adult
medicine.medical_specialty
Adolescent
Population
Article
Young Adult
03 medical and health sciences
Internal medicine
Humans
education
Glucocorticoids
Aged
Dose-Response Relationship
Drug
business.industry
Eyelids
Hyperthermia
Induced
medicine.disease
Ophthalmology
030221 ophthalmology & optometry
Ophthalmic Solutions
business
Follow-Up Studies
Zdroj: Acta Ophthalmologica. 96:e503-e509
ISSN: 1755-375X
DOI: 10.1111/aos.13675
Popis: PURPOSE To assess the within-treatment efficacy of hot compresses (HC), HC plus tobramycin (Tobrex) and HC plus tobramycin/dexamethasone (Tobradex) for chalazia treatment. METHODS Design: Multicentre, randomized clinical trial (ClinicalTrials.gov identifier, NCT01230593). SETTING Two clinical sites in New York and two clinical sites in Ontario. STUDY POPULATION A total of 149 patients with one or more chalazia on separate eyelids randomly assigned to receive HC (n = 50), HC plus tobramycin (n = 50) or HC plus tobramycin/dexamethasone (n = 49). INTERVENTION 4-6 weeks of assigned treatment. Patients were measured for chalazion horizontal width and surveyed for pain and treatment satisfaction levels. MAIN OUTCOME MEASURES Primary outcome was complete resolution (100% size reduction). Secondary outcomes were size change in millimetres and patient reported pre- and post-treatment pain and satisfaction levels. RESULTS In the intention-to-treat (ITT) population, complete resolution occurred in 36 (18%) lesions total, 13 (21%) treated with HC, 12 (16%) with HC plus tobramycin and 11 (18%) with HC plus tobramycin/dexamethasone, with no significant difference between them (p = .78). Individually by paired t-test, there were statistically significant post-treatment mean size differences: HC 1.20 mm (p
Databáze: OpenAIRE
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