Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection
| Autor: | Carla Polycarpo, Magda D. Lugon, Emmanuelle Jacquin-Joly, Francisco Prosdocimi, Katia C. Gondim, Daniel Lawson, Raquel J. Vionette-Amaral, Karyn Megy, Andrew Pike, Fernando A. Monteiro, David Majerowicz, Marco Mariotti, Gloria I. Giraldo-Calderón, Fernando G. Noriega, Ana Beatriz Walter-Nuno, M. Patricia Juárez, Leonardo Koerich, A. Bernardo Carvalho, Marcos Sterkel, Fernando Abad-Franch, Catrina Fronick, Samara G. da Costa, Eloy S. Seabra-Junior, Márcio G. Pavan, Pedro L. Oliveira, Willy Jablonka, Myriam Harry, Ana C.A. Melo, Rita D. Fernandez-Medina, George Dimopoulos, Igor Rodrigues da Costa, Cristiano Lazoski, Alessandra A. Guarneri, Paula L. Marcet, Lucinda Fulton, Gena G. Lawrence, Patrícia Azambuja, Gabriela O. Paiva-Silva, Adriana Granzotto, Francisco Panzera, Marcelo G. Lorenzo, Didac Santesmasses, Raquel L.L. Oliveira, Ricardo Nascimento Araújo, Hugh M. Robertson, Renata Schama, Matheus Souza-Gomes, Didier Salmon, Iron F. De-Paula, José M. C. Ribeiro, Roderic Guigó, Derek Wilson, Ana Caroline P. Gandara, Rolando Rivera-Pomar, André Q. Torres, Raul Ursic-Bedoya, Andrés Lavore, Scott J. Emrich, Marcio Fontenele, Laurence Rodrigues do Amaral, Felipe A. Dias, Mário A.C. Silva-Neto, Claudia M. A. Carareto, John Spieth, Nicolás Pedrini, Erwin Huebner, Claudio R. Lazzari, Rafael D. Mesquita, Helena Araujo, Ian Orchard, Fernando A. Genta, Daniel S.T. Hughes, Zhijian Jake Tu, Carl Lowenberger, Paula R. Bittencourt-Cunha, Marcos Henrique Ferreira Sorgine, Michael J. Montague, Rodrigo Nunes da Fonseca, Gustavo M. Calderón-Fernández, Alexandre A. Peixoto, Marcela Nouzova, Angela B. Lange, Gilbert Oliveira-Silveira, Eloi S. Garcia, L. Aravind, Ellen M. Dotson, Hatisaburo Masuda, Glória R.C. Braz, Bruno Gomes, Natalia Esponda-Behrens, Raphael R.S. Lopes, Marilvia Dansa, Sheila Ons, Patrícia Fampa, Rodrigo Dutra Nunes, Mikkel B. Christensen, Ana Paula Salerno, Mabel L. Taracena, Marta Tojo, Georgia C. Atella, Jose Manuel Latorre-Estivalis, Marcos H. Pereira, Agustina Pascual, Michele Alves-Bezerra, Robert M. Waterhouse, Theo Mota, Rodrigo Ribeiro-Rodrigues, Thiago M. Venancio, Lucia Pagola, Fanis Missirlis, Carlos R. O. Daumas-Filho, Jose M. C. Tubio, Lívia Silva-Cardoso, Wesley C. Warren, Richard K. Wilson, Patrick Minx, Mateus Berni |
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| Přispěvatelé: | Mesquita, Rafael D., Vionette Amaral, Raquel J., Departamento de Bioquimica, UNICAMP, Institut de recherche sur la biologie de l'insecte UMR7261 (IRBI), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), National Institutes of Health Grant [NHGRI-HG003079], National Institutes of Health National Institute of Allergy and Infectious Diseases Grant [HHSN272200900039C], Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Fundacao de Amparo a Pesquisa do Estado de Minas Gerais, Consejo Nacional de Investigaciones Cientificas y Tecnicas de Argentina, Agencia Nacional de Promocion de Ciencia y Tecnologia, Fundacion Bunge y Born, Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/FAPERJ, [PIOF-GA-2011-303312], Université de Tours-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0106 biological sciences
Chagas disease Biología [SDV]Life Sciences [q-bio] ved/biology.organism_classification_rank.species maladie de chagas 01 natural sciences Genome purl.org/becyt/ford/1 [https] rhodnius prolixus Putative gene ddc:576.5 Genetics 0303 health sciences Multidisciplinary Host-Parasite Interactions/genetics RHODNIUS PROLIXUS Ecology Trypanosoma cruzi/physiology Adaptation Physiological/genetics Biological Sciences 3. Good health GENOME Wolbachia Wolbachia/genetics Gene Transfer Horizontal hematophagy Hematophagy Rhodnius Molecular Sequence Data Rhodnius prolixus genome immunity Biology IMMUNITY 010603 evolutionary biology 03 medical and health sciences Animals Humans Model organism purl.org/becyt/ford/1.6 [https] Gene Rhodnius/genetics/parasitology 030304 developmental biology Base Sequence ved/biology CHAGAS DISEASE biology.organism_classification Insect Vectors/genetics/parasitology HEMATOPHAGY |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America 48 (112), 14936-14941. (2015) Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (48), pp.14936-14941. ⟨10.1073/pnas.1506226112⟩ CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Proceedings of the National Academy of Sciences, Vol. 112, No 48 (2015) pp. 14936-14941 SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| ISSN: | 0027-8424 1091-6490 |
| Popis: | Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is a major vector of Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced the genome of R. prolixus, generated assembled sequences covering 95% of the genome (∼702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses of this obligate blood-feeding insect. Although immunedeficiency (IMD)-mediated immune responses were observed, R. prolixus putatively lacks key components of the IMD pathway, suggesting a reorganization of the canonical immune signaling network. Although both Toll and IMD effectors controlled intestinal microbiota, neither affected Trypanosoma cruzi, the causal agent of Chagas disease, implying the existence of evasion or tolerance mechanisms. R. prolixus has experienced an extensive loss of selenoprotein genes, with its repertoire reduced to only two proteins, one of which is a selenocysteine-based glutathione peroxidase, the first found in insects. The genome contained actively transcribed, horizontally transferred genes from Wolbachia sp., which showed evidence of codon use evolution toward the insect use pattern. Comparative protein analyses revealed many lineage-specific expansions and putative gene absences in R. prolixus, including tandem expansions of genes related to chemoreception, feeding, and digestion that possibly contributed to the evolution of a blood-feeding lifestyle. The genome assembly and these associated analyses provide critical information on the physiology and evolution of this important vector species and should be instrumental for the development of innovative disease control methods. La lista completa de autores que integran el documento puede consultarse en el archivo Este documento tiene una corrección (ver documento relacionado). Centro Regional de Estudios Genómicos Instituto de Investigaciones Bioquímicas de La Plata |
| Databáze: | OpenAIRE |
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