A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease
| Autor: | M.C.G.J. van der Linden, J.W.M. van der Meer, R. P. Mouton, Alexander A.W. Peters, E.J.M. van Erp, E.H. Witte, I.B.C. Smit |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Antibiotics Chlamydia trachomatis medicine.disease_cause Gastroenterology Pefloxacin Double-Blind Method Internal medicine Metronidazole Pelvic inflammatory disease medicine Humans Laparoscopy GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Doxycycline Chemotherapy medicine.diagnostic_test business.industry Obstetrics and Gynecology Surgery Treatment Outcome Reproductive Medicine Acute Disease Drug Therapy Combination Female business medicine.drug Pelvic Inflammatory Disease |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology, 50, 153-158 European Journal of Obstetrics & Gynecology and Reproductive Biology, 50, 2, pp. 153-158 |
| ISSN: | 0301-2115 |
| Popis: | A double-blind, randomised study was conducted to compare the efficacy and safety of a combination of pefloxacin and metronidazole versus doxycycline and metronidazole in patients with pelvic inflammatory disease (PID). The clinical diagnosis had to be confirmed by laparoscopy before patients were included. Of the 74 patients who fulfilled the clinical criteria for PID, laparoscopy confirmed the diagnosis in only 40 patients (54%). The microorganism most frequently found as causative pathogen was Chlamydia trachomatis. Both treatment groups showed a good response to the study-medication. At discharge 9 patients in the pefloxacin group (45%) were cured and 10 patients (50%) had improved. In the doxycycline group 7 patients (35%) were cured and 10 patients (50%) had improved. Obviously pefloxacin/metronidazole and doxycycline/metronidazole are equally effective in the treatment of PID. |
| Databáze: | OpenAIRE |
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