X-ray-induced Glomerulosclerosis in Rats: Modification of Lesion by Food Restriction, Uninephrectomy, and Age
| Autor: | Louis W. Wachtel, Leonard J. Cole, Victor J. Rosen |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Aging
Kidney Pathology medicine.medical_specialty Nephrosclerosis Growth retardation Body Weight Weanling Glomerulosclerosis Organ Size Biology medicine.disease Body weight Nephrectomy Renal Veins Rats Food restriction Lesion Radiation Injuries Experimental medicine.anatomical_structure Food medicine Animals medicine.symptom |
| Zdroj: | Journal of Gerontology. 21:442-448 |
| ISSN: | 0022-1422 |
| DOI: | 10.1093/geronj/21.3.442 |
| Popis: | The development of glomerulosclerosis was measured in the kidneys of rats under various conditions of irradiation and growth. Weanling rats showe kidneys were irradiated directly with 1,000 rad or 2,000 rad developed glomerulosclerotic lesions in 2 months; one-year old rats showed no evidence of lesions 2 months after irradiation with 2,000 rad. In the weanling rat the rapidity of development and severity of the glomerulosclerotic lesions were increased by growth or enlargement of the kidney subsequent to irradiation, and were slowed by growth retardation artificially produced through low-food intake. The induction of glomerulosclerosis by X-irradiation of the kidney is believed to be a latent result of damage to the kidney's vascular system, and that effects of this damage are accentuated in the growing kidney. (Author) |
| Databáze: | OpenAIRE |
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