How do plasma-generated OH radicals react with biofilm components? Insights from atomic scale simulations
| Autor: | Annemie Bogaerts, Erik C. Neyts, Stijn Huygh, Maksudbek Yusupov, Narjes Khosravian |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Alkane
chemistry.chemical_classification Reaction mechanism Biomolecule Radical Carboxylic acid Physics Biofilm General Physics and Astronomy Atmospheric-pressure plasma General Chemistry Photochemistry Hydrogen atom abstraction General Biochemistry Genetics and Molecular Biology Biomaterials Chemistry chemistry Organic chemistry General Materials Science Biology |
| Zdroj: | Biointerphases |
| ISSN: | 1559-4106 |
| Popis: | The application of nonthermal atmospheric pressure plasma is emerging as an alternative and efficient technique for the inactivation of bacterial biofilms. In this study, reactive molecular dynamics simulations were used to examine the reaction mechanisms of hydroxyl radicals, as key reactive oxygen plasma species in biological systems, with several organic molecules (i.e., alkane, alcohol, carboxylic acid, and amine), as prototypical components of biomolecules in the biofilm. Our results demonstrate that organic molecules containing hydroxyl and carboxyl groups may act as trapping agents for the OH radicals. Moreover, the impact of OH radicals on N-acetyl-glucosamine, as constituent component of staphylococcus epidermidis biofilms, was investigated. The results show how impacts of OH radicals lead to hydrogen abstraction and subsequent molecular damage. This study thus provides new data on the reaction mechanisms of plasma species, and particularly the OH radicals, with fundamental components of bacterial biofilms. |
| Databáze: | OpenAIRE |
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