Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review

Autor:	Javier De Diego-Adeliño, José Manuel Crespo, Fernando Mora, Adrián Neyra, Pedro Iborra, Luis Gutiérrez-Rojas, Selman F. Salonia
Rok vydání:	2021
Předmět:	Depressive Disorder Major Serotonin Humans Female Vortioxetine Pharmacology (medical) General Medicine Sulfides Antidepressive Agents Piperazines
Zdroj:	Expert Opinion on Drug Safety. 21:673-690
ISSN:	1744-764X 1474-0338
Popis:	Vortioxetine is a multimodal-acting antidepressant that provides improvements on cognitive function aside from antidepressants and anxiolytic effects. Vortioxetine has been found to be one of the most effective and best tolerated options for major depressive disorder (MDD) in head-to-head trials.The present review intends to gather the most relevant and pragmatic data of vortioxetine in MDD, specially focusing on new studies that emerged between 2015 and 2020.Vortioxetine is the first antidepressant that has shown improvements both in depression and cognitive symptoms, due to the unique multimodal mechanism of action that combine the 5-HT reuptake inhibition with modulations of other key pre- and post-synaptic 5-HT receptors (agonism of 5-HT
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2bf0754784e47909f9b011580098f4 https://doi.org/10.1080/14740338.2022.2019705 Zobrazit plný text záznamu