APACHE-II score for anti-tuberculosis tolerance in critically ill patients: a retrospective study
| Autor: | Xiaohong Pan, Minjie Mao, Lei Pan, Junke Qiu, Caihong Wang, Jiekun Xu, Xiao-bo Ji, Xiao-qing Huang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty APACHE-II Critical Illness 030106 microbiology Antitubercular Agents Comorbidity Sensitivity and Specificity lcsh:Infectious and parasitic diseases 03 medical and health sciences Drug withdrawal 0302 clinical medicine Interquartile range Internal medicine medicine Humans Tuberculosis lcsh:RC109-216 030212 general & internal medicine APACHE Aged Retrospective Studies Aged 80 and over COPD APACHE II Receiver operating characteristic business.industry Retrospective cohort study Odds ratio Middle Aged medicine.disease Prognosis Confidence interval Infectious Diseases Withholding Treatment Female business Drug tolerance Research Article |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019) |
| ISSN: | 1471-2334 |
| Popis: | Background To investigate the status of anti-tuberculosis treatment in critically ill patients, and to explore the value of APACHE-II score in guiding anti-tuberculosis treatment. Methods This analysis included critically ill patients with tuberculosis. The utility of APACHE-II score for predicting drug withdrawal was evaluated using receiver operating characteristic (ROC) curve analysis. Results Among 320 patients enrolled (58 ± 22 years; 256 males), 147 (45.9%) had drugs withdrawn. The drug withdrawal group had higher APACHE-II score (median [interquartile range]: 21 [3–52] vs. 17 [4–42] points), higher CD4%, lower hemoglobin level, higher rates of chronic obstructive pulmonary disease (COPD) and chronic renal failure, and lower rate of extrapulmonary tuberculosis (P 18 (odds ratio [95% confidence interval]: 2.099 [1.321–3.334], P 18 points might predict patient tolerance of anti-tuberculosis treatment. |
| Databáze: | OpenAIRE |
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