Incidence of sudden cardiac death associated with coronary artery occlusion in dogs with hypertension and left ventricular hypertrophy is reduced by chronic beta-adrenergic blockade
| Autor: | Melvin L. Marcus, J. L. Clothier, Kevin C. Dellsperger, James B. Martins |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Heart Ventricles Adrenergic beta-Antagonists Myocardial Infarction Cardiomegaly Coronary Disease Left ventricular hypertrophy Sudden death Sudden cardiac death Death Sudden Dogs Enalapril Risk Factors Coronary Circulation Physiology (medical) Internal medicine medicine Animals cardiovascular diseases Metoprolol business.industry Hemodynamics medicine.disease Blood pressure Coronary occlusion Anesthesia Hypertension cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Circulation. 82:941-950 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.82.3.941 |
| Popis: | Because beta-adrenergic blockade has as one of its many effects altered electrophysiological abnormalities after dogs with left ventricular hypertrophy have been subjected to coronary occlusion, we tested the hypothesis that metoprolol (200-400 mg/day) would reduce mortality rates in dogs with one-kidney, one clip left ventricular hypertrophy while a similar reduction in arterial pressure with enalapril (20-40 mg/day) would not. Dogs with left ventricular hypertrophy were given metoprolol or enalapril for 5-7 days before a 3-hour coronary occlusion. Infarct size and risk area were measured with triphenyltetrazolium chloride stain and barium angiography, respectively. For control (n = 15), left ventricular hypertrophy (n = 17), left ventricular hypertrophy plus metoprolol (n = 12), and left ventricular hypertrophy plus enalapril (n = 15) groups, mean arterial pressure, ratio of infarct size to risk area, and dogs experiencing sudden death were 110 +/- 4, 142 +/- 4, 121 +/- 7, and 120 +/- 3 mm Hg; 44 +/- 5%, 65 +/- 5%, 44 +/- 7%, and 30 +/- 4%; and 27%, 65%, 17%, and 53%, respectively. Thus, the excessive increase in early mortality occurring when dogs with hypertension and left ventricular hypertrophy undergo coronary occlusion is interrupted with beta-blockade, possibly via electrophysiological effects rather than by changes in arterial pressure or infarct size. |
| Databáze: | OpenAIRE |
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