Relationship between Anticholinergic Burden and Health-Related Quality of Life among Residents in Long-Term Care

Autor: Hanna-Maria Roitto, Hannareeta Öhman, Hannu Kautiainen, Harriet Finne-Soveri, Kaisu H. Pitkälä, Ulla L. Aalto
Přispěvatelé: Department of General Practice and Primary Health Care, Clinicum, Department of Medicine, Teachers' Academy, HUS Helsinki and Uusimaa Hospital District
Rok vydání: 2020
Předmět:
Male
Gerontology
Cross-sectional study
medicine.drug_class
Anticholinergic burden
Medicine (miscellaneous)
DRUG-USE
CROSS-SECTIONAL ANALYSIS
Cholinergic Antagonists
HRQoL
03 medical and health sciences
0302 clinical medicine
Quality of life
MEDICATION USE
Anticholinergic
medicine
Humans
Dementia
OLDER-PEOPLE
030212 general & internal medicine
Aged
Aged
80 and over
2. Zero hunger
Health related quality of life
OUTCOMES
BENEFICIARIES
Nutrition and Dietetics
RISK SCALE
business.industry
DEMENTIA
NURSING-HOME RESIDENTS
Cognition
ASSOCIATION
16. Peace & justice
medicine.disease
3142 Public health care science
environmental and occupational health
nursing home
Long-term care
Cross-Sectional Studies
Quality of Life
long-term care
Female
3143 Nutrition
Geriatrics and Gerontology
business
Older people
030217 neurology & neurosurgery
Zdroj: The journal of nutrition, health & aging. 25:224-229
ISSN: 1760-4788
1279-7707
Popis: Objectives Anticholinergic burden defined by the Anticholinergic Risk Scale (ARS) has been associated with cognitive and functional decline. Associations with health-related quality of life (HRQoL) have been scarcely studied. The aim of this study was to examine the association between anticholinergic burden and HRQoL among older people living in long-term care. Further, we investigated whether there is an interaction between ARS score and HRQoL in certain underlying conditions. Design and participants Cross-sectional study in 2017. Participants were older people residing in long-term care facilities (N=2474) in Helsinki. Measurements Data on anticholinergic burden was assessed by ARS score, nutritional status by Mini Nutritional Assessment, and HRQoL by the 15D instrument. Results Of the participants, 54% regularly used ARS-defined drugs, and 22% had ARS scores ≥2. Higher ARS scores were associated with better cognition, functioning, nutritional status and higher HRQoL. When viewing participants separately according to a diagnosis of dementia, nutritional status or level of dependency, HRQoL was lower among those having dementia, worse nutritional status, or being dependent on another person’s help (adjusted for age, sex, comorbidities). Significant differences within the groups according to ARS score were no longer observed. However, interactions between ARS score and dementia and dependency emerged. Conclusion In primary analysis there was an association between ARS score and HRQoL. However, this relationship disappeared after stratification by dementia, nutritional status and dependency. The reasons behind the interaction concerning dementia or dependency remain unclear and warrant further studies.
Databáze: OpenAIRE
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