Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter Study
| Autor: | Lise Bérard, C.E. Lavoignet, Laure Abensur Vuillaume, François Lefebvre, Sylvie Chabrier, Pierrick Le Borgne, Pauline Haessler, Pascal Bilbault, Karine Alamé, Stéphane Gennai |
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| Přispěvatelé: | Centre Hospitalier Universitaire de Reims (CHU Reims) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty [SDV]Life Sciences [q-bio] severity Disease 030204 cardiovascular system & hematology Microbiology Article law.invention Pathogenesis 03 medical and health sciences COVID-19 eosinophils eosinopenia mortality 0302 clinical medicine law Virology Internal medicine medicine Eosinopenia 030212 general & internal medicine lcsh:QH301-705.5 business.industry Outbreak Retrospective cohort study Emergency department medicine.disease Intensive care unit 3. Good health lcsh:Biology (General) Cohort business |
| Zdroj: | Microorganisms; Volume 9; Issue 2; Pages: 334 Microorganisms Microorganisms, MDPI, 2021, 9 (2), pp.334. ⟨10.3390/microorganisms9020334⟩ Microorganisms, Vol 9, Iss 334, p 334 (2021) |
| ISSN: | 2076-2607 |
| DOI: | 10.3390/microorganisms9020334 |
| Popis: | Introduction: Healthcare systems worldwide have been battling the ongoing COVID-19 pandemic. Eosinophils are multifunctional leukocytes implicated in the pathogenesis of several inflammatory processes including viral infections. We focus our study on the prognostic value of eosinopenia as a marker of disease severity and mortality in COVID-19 patients. Methods: Between 1 March and 30 April 2020, we conducted a multicenter and retrospective study on a cohort of COVID-19 patients (moderate or severe disease) who were hospitalized after presenting to the emergency department (ED). We led our study in six major hospitals of northeast France, one of the outbreak’s epicenters in Europe. Results: We have collected data from 1035 patients, with a confirmed diagnosis of COVID-19. More than three quarters of them (76.2%) presented a moderate form of the disease, while the remaining quarter (23.8%) presented a severe form requiring admission to the intensive care unit (ICU). Mean circulating eosinophils rate, at admission, varied according to disease severity (p < 0.001), yet it did not differ between survivors and non-survivors (p = 0.306). Extreme eosinopenia (=0/mm3) was predictive of severity (aOR = 1.77, p = 0.009); however, it was not predictive of mortality (aOR = 0.892, p = 0.696). The areas under the Receiver operating characteristics (ROC) curve were, respectively, 58.5% (CI95%: 55.3–61.7%) and 51.4% (CI95%: 46.8–56.1%) for the ability of circulating eosinophil rates to predict disease severity and mortality. Conclusion: Eosinopenia is very common and often profound in cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Eosinopenia was not a useful predictor of mortality; however, undetectable eosinophils (=0/mm3) were predictive of disease severity during the initial ED management. |
| Databáze: | OpenAIRE |
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