Serologic IgG response to urease in Helicobacter pylori-infected persons from Mexico
| Autor: | Guillermo I. Perez-Perez, A. Gómez, Javier Torres, R Tapia-Conyer, Onofre Muñoz, Yelda Aurora Leal-Herrera, T Monath |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Aging medicine.medical_specialty Adolescent Spirillaceae Population Enzyme-Linked Immunosorbent Assay Helicobacter Infections Serology Immune system Antigen Seroepidemiologic Studies Virology Epidemiology medicine Humans Colonization Child education Mexico Aged Aged 80 and over Antigens Bacterial education.field_of_study Helicobacter pylori biology Infant Newborn Infant biology.organism_classification Antibodies Bacterial Urease Infectious Diseases Socioeconomic Factors Child Preschool Immunoglobulin G Immunology Parasitology |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 60:587-592 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1999.60.587 |
| Popis: | Helicobacter pylori urease is required to counteract acidity during colonization of the stomach, and has been suggested as a major immunodominant antigen. The aim of this study was to determine the anti-urease response in a representative national serologic survey in Mexico. The population surveyed included persons 1-90 years of age from all socioeconomic levels and geographic zones of the country. Helicobacter pylori status was determined by ELISA serology. The IgG anti-urease was studied by ELISA using a recombinant apoenzyme. We found that 2,930 of the 7,720 infected patients (38%) were seropositive for IgG urease. The rate of IgG anti-urease positivity increased with age; in children10 years old it was20% and in persons40 years old it was50%. Age and a region with a high level of development were risk factors for seropositivity, whereas gender, educational level, crowding, and socioeconomic level were not associated with seropositivity. In conclusion, in natural infection with H. pylori, the response to urease is poor, mainly during the first years of infection. This inconsistent immune response to the enzyme may favor persistence of infection. A vaccine eliciting a consistent anti-urease response might overcome immune evasion and enhance clearance of bacteria after exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|