Methylene Blue Loaded Cu–Tryptone Complex Nanoparticles: A New Glutathione-Reduced Enhanced Photodynamic Therapy Nanoplatform
| Autor: | Xiue Jiang, Chao Wang, Xiaodan Jia, Wenyao Zhen, Yudi Ruan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species medicine.medical_treatment 0206 medical engineering Biomedical Engineering Photodynamic therapy 02 engineering and technology Glutathione 021001 nanoscience & nanotechnology 020601 biomedical engineering Biomaterials chemistry.chemical_compound chemistry In vivo Cancer cell medicine Biophysics Photosensitizer 0210 nano-technology Methylene blue Intracellular |
| Zdroj: | ACS Biomaterials Science & Engineering. 5:1016-1022 |
| ISSN: | 2373-9878 |
| Popis: | The concentration of intracellular reactive oxygen species directly determines the effect of photodynamic therapy. Reducing intracellular glutathione (GSH) content can increase reactive oxygen species (ROS) level. Therefore, it is extremely important to construct a nanoplatform that can promote photodynamic therapy by consuming GSH. In this study, we synthesized Cu-typtone complex nanoparticles (Cu-Try NPs) by a simple green method and demonstrated their ability to consume GSH to increase intracellular ROS for the first time. Photosensitizer methylene blue was loaded onto Cu-Try NPs (Cu-Try/MB NPs) for enhanced photodynamic therapy. Studies in vitro and in vivo illustrated that enhanced photodynamic therapy based on Cu-Try/MB NPs can kill cancer cells effectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|