Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males
| Autor: | Charles W. Wilkinson, Daniel M. Dorsa, M. Michele Murburg, Richard C. Veith, Kenneth L. Malas, David Paly |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Pituitary gland Time Factors Hydrocortisone Dopamine Radioimmunoassay General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine Blood plasma medicine Haloperidol Humans General Pharmacology Toxicology and Pharmaceutics Neurotransmitter Behavior business.industry Dopaminergic beta-Endorphin Dopamine antagonist General Medicine Circadian Rhythm medicine.anatomical_structure Endocrinology chemistry Dopaminergic pathways Endorphins business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Life sciences. 39(4) |
| ISSN: | 0024-3205 |
| Popis: | To investigate possible central dopaminergic regulation of beta-endorphin-like immunoreactivity (beta E-LI) and adrenocorticotropin (ACTH) release in humans, we gave the dopamine antagonist haloperidol or placebo intravenously to twelve normal male subjects and measured beta E-LI and cortisol for 120 minutes following injection. Haloperidol, but not placebo, produced significant increases in plasma beta E-LI and cortisol. These findings suggest that central dopaminergic pathways such as the tuberohypophyseal system may participate in regulation of the secretion of beta E and ACTH from the human pituitary. |
| Databáze: | OpenAIRE |
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