Cytotoxic acridone and indoloquinazoline alkaloids from Zanthoxylum poggei
| Autor: | Satyajit D. Sarker, Flavien A. A. Toze, Alain Tadjong Tcho, Jean Duplex Wansi, Lutfun Nahar, Claire Martin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
RM
food.ingredient Stereochemistry RV Plant Science medicine.disease_cause 01 natural sciences Biochemistry chemistry.chemical_compound food Zanthoxylum medicine Agar IC50 biology 010405 organic chemistry Zymosan Pathogenic bacteria biology.organism_classification In vitro 0104 chemical sciences Acridone 010404 medicinal & biomolecular chemistry Phytochemical chemistry Agronomy and Crop Science Biotechnology |
| Zdroj: | Phytochemistry Letters. 17:293-298 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2016.08.010 |
| Popis: | Two new alkaloids, poggeicridone (1) and 2-methoxy-7,8- dehydroruteacarpine (6), together with nine known compounds, were isolated from the dichloromethane (DCM) extract of the bark of Zanthoxylum poggei (Engl.) P. G. Waterman. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR and EI- and ESI–MS). Compounds 5-9 exhibited strong suppressive effects on the phagocytosis response upon activation with serum opsonized zymosan in the in vitro oxidative burst studies using whole blood. The IC50 values were in the range of 12.0–25.9 μM. These compounds displayed a moderate level of cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3, with IC50 values of 15.8 and 22.1 μM (the IC50 value of the positive control standard doxorubicin was IC50 0.9 μM). All isolated compounds were also tested against plant pathogenic bacteria, fungi and oomycetes using the paper disk agar diffusion assay, resulting in no significant activities (MICs > 1 mg/mL). © 2016 Phytochemical Society of Europe |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect