Deterioration of Cortical and Trabecular Microstructure Identifies Women With Osteopenia or Normal Bone Mineral Density at Imminent and Long‐Term Risk for Fragility Fracture: A Prospective Study

Autor: Ego Seeman, Roland Chapurlat, Elisabeth Sornay-Rendu, Eric Lespessailles, Pierre D. Delmas, Roger Zebaze, Danny Liew, Minh Bui
Přispěvatelé: Imagerie Multimodale Multiéchelle et Modélisation du Tissu Osseux et articulaire (I3MTO), Université d'Orléans (UO), Hospices Civils de Lyon (HCL), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Physiopathologie des Osteopathies Fragilisantes, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Adult
musculoskeletal diseases
medicine.medical_specialty
FRAX
Bone density
Endocrinology
Diabetes and Metabolism
Osteoporosis
030209 endocrinology & metabolism
Risk Assessment
03 medical and health sciences
Fractures
Bone
0302 clinical medicine
Bone Density
Risk Factors
Internal medicine
medicine
Humans
Orthopedics and Sports Medicine
Prospective Studies
Prospective cohort study
Child
ComputingMilieux_MISCELLANEOUS
Aged
Bone mineral
Aged
80 and over
microstructural deterioration
normal BMD
business.industry
musculoskeletal
neural
and ocular physiology
Odds ratio
Middle Aged
medicine.disease
musculoskeletal system
osteoporosis
Osteopenia
imminent fracture risk
Bone Diseases
Metabolic
030104 developmental biology
osteopenia
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Child
Preschool
Cohort
Female
business
Osteoporotic Fractures
Zdroj: Journal of Bone and Mineral Research
Journal of Bone and Mineral Research, American Society for Bone and Mineral Research, 2020, 35 (5), pp.833-844. ⟨10.1002/jbmr.3924⟩
ISSN: 0884-0431
DOI: 10.1002/jbmr.3924⟩
Popis: More than 70% of women sustaining fractures have osteopenia or “normal” bone mineral density (BMD). These women remain undetected using the BMD threshold of −2.5 SD for osteoporosis. As microstructural deterioration increases bone fragility disproportionate to the bone loss producing osteopenia/normal BMD, we hypothesized that the structural fragility score (SFS) of ≥70 units, a measure capturing severe cortical and trabecular deterioration, will identify these women. Distal radial images were acquired using high‐resolution peripheral quantitative tomography in postmenopausal French women, mean age 67 years (range 42–96 years); 1539 women were followed for 4 years (QUALYOR) and 561 women followed for 8 years (OFELY). Women with osteopenia or normal BMD accounted for ~80% of fractures. Women ≥70 years, 29.2% of the cohort, accounted for 39.2% to 61.5% of fractures depending on follow‐up duration. Women having fractures had a higher SFS, lower BMD, and a higher fracture risk assessment score (FRAX) than women remaining fracture‐free. In each BMD category (osteoporosis, osteopenia, normal BMD), fracture incidence was two to three times higher in women with SFS ≥70 than
Databáze: OpenAIRE
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