Cell surface-anchored serine proteases in cancer progression and metastasis
| Autor: | Karin List, Carly E. Martin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Proteases Glycosylphosphatidylinositols Biology medicine.disease_cause TMPRSS2 Article Metastasis Serine 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Animals Humans Matriptase Neoplasm Metastasis Serine protease Cell Membrane Cancer medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis biology.protein Cancer research Disease Progression Serine Proteases Carcinogenesis |
| Zdroj: | Cancer Metastasis Rev |
| ISSN: | 1573-7233 |
| Popis: | Over the last two decades, a novel subgroup of serine proteases, the cell surface-anchored serine proteases, has emerged as an important component of the human degradome, and several members have garnered significant attention for their roles in cancer progression and metastasis. A large body of literature describes that cell surface-anchored serine proteases are deregulated in cancer and that they contribute to both tumor formation and metastasis through diverse molecular mechanisms. The loss of precise regulation of cell surface-anchored serine protease expression and/or catalytic activity may be contributing to the etiology of several cancer types. There is therefore a strong impetus to understand the events that lead to deregulation at the gene and protein levels, how these precipitate in various stages of tumorigenesis, and whether targeting of selected proteases can lead to novel cancer intervention strategies. This review summarizes current knowledge about cell surface-anchored serine proteases and their role in cancer based on biochemical characterization, cell culture-based studies, expression studies, and in vivo experiments. Efforts to develop inhibitors to target cell surface-anchored serine proteases in cancer therapy will also be summarized. |
| Databáze: | OpenAIRE |
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