Transgenic mice expressing a human mutant beta1 thyroid receptor are hyperactive, impulsive, and inattentive
| Autor: | L. R. Miller, S. Y. Cheng, Jiali Zhao, W. B. Siesser, Michael P. McDonald |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Thyroid Hormone Resistance Syndrome Genetically modified mouse Thyroid Hormones medicine.medical_specialty Transgene Mice Transgenic Hyperkinesis Impulsivity Mice Behavioral Neuroscience Internal medicine mental disorders Genetics medicine Animals Humans Attention deficit hyperactivity disorder Attention Genetic Predisposition to Disease Euthyroid Transgenes Analysis of Variance Thyroid hormone receptor Methylphenidate Genes erbA Thyroid Age Factors Thyroid Hormone Receptors beta medicine.disease Disease Models Animal Endocrinology medicine.anatomical_structure Neurology Attention Deficit Disorder with Hyperactivity Impulsive Behavior Mutation Exploratory Behavior Central Nervous System Stimulants Female medicine.symptom Psychology medicine.drug |
| Zdroj: | Genes, Brain and Behavior. 5:282-297 |
| ISSN: | 1601-183X 1601-1848 |
| Popis: | Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed childhood psychiatric disorder. We have found that a transgenic mouse bearing a human mutant thyroid receptor (TRbeta1) expresses all of the defining symptoms of ADHD--inattention, hyperactivity, and impulsivity--as well as a 'paradoxical' response to methylphenidate (MPH). As with ADHD, the behavioral phenotypes expressed by the TRbeta transgenic mice are dynamic and sensitive to changes in environmental conditions, stress, and reinforcement. TRbeta transgenic mice are euthyroid except for a brief period during postnatal development, but the behavioral phenotypes, elevated dopamine turnover, and paradoxical response to MPH persist into adulthood. Thus, like the vast majority of children with ADHD, the TRbeta transgenic mice exhibit the symptoms of ADHD in the complete absence of thyroid abnormalities. This suggests that even transient perturbations in developmental thyroid homeostasis can have long-lasting behavioral and cognitive consequences, including producing the full spectrum of symptoms of ADHD. |
| Databáze: | OpenAIRE |
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