Glucose-6-Phosphate Dehydrogenase Deficiency and the Sickle Cell Gene in Makkah, Saudi Arabia
| Autor: | Hassan H. Bahakim, Mohsen A. F. El-Hazmi, Arjumand S. Warsy, Abdulrahman Al-Swailem |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Hemolytic anemia Heterozygote Anemia Hemoglobin Sickle Saudi Arabia Physiology Anemia Sickle Cell Biology Gene Frequency medicine Humans Allele frequency Genetics Hemoglobin E Incidence Homozygote Heterozygote advantage medicine.disease Sickle cell anemia Glucosephosphate Dehydrogenase Deficiency Phenotype Infectious Diseases Hemoglobinopathy Pediatrics Perinatology and Child Health Female Hemoglobin Glucose-6-phosphate dehydrogenase deficiency |
| Zdroj: | Journal of Tropical Pediatrics. 40:12-16 |
| ISSN: | 1465-3664 0142-6338 |
| DOI: | 10.1093/tropej/40.1.12 |
| Popis: | This study was conducted on 689 Saudi males and females living in the Makkah area in the western province of Saudi Arabia. The frequency of severe glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in the male and female populations was 0.055 and 0.042 respectively. The normal G-6-PD was G-6-PD-B+ and the G-6-PD phenotypes identified included G-6-PD-A+, G-6-PD-A-, G-6-PD-Mediterranean, and G-6-PD-Mediterranean-like at gene frequencies of 0.0288, 0.0026, 0.05497, and 0.1969 in the male population and 0.026, 0.0146, 0.0407, and 0.02606 in the female population. The main variants producing severe and mild G-6-PD deficiency were G-6-PD-Mediterranean and G-6-PD-Mediterranean-like, respectively. The sickle cell gene was identified at a frequency of 0.029 and no interaction between sickle cell and G-6-PD deficiency genes was encountered. |
| Databáze: | OpenAIRE |
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