First report of polymyxin B activity in Klebsiella pneumoniae biofilm
| Autor: | Michael Eder De Oliveira, Jaqueline Maria Siqueira Ferreira, Adriana Cristina Soares, Fernanda Kelen da Silva, Magna Cristina de Paiva, Karina Marjorie Silva Herrera |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Klebsiella pneumoniae 030106 microbiology Microbial Sensitivity Tests Urine Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Pharmacology (medical) Polymyxin B Pharmacology Polysorbate biology Chemistry Biofilm biochemical phenomena metabolism and nutrition biology.organism_classification Anti-Bacterial Agents Klebsiella Infections Clinical Practice Infectious Diseases Oncology Biofilms 030220 oncology & carcinogenesis medicine.drug |
| Zdroj: | Journal of Chemotherapy. 31:127-131 |
| ISSN: | 1973-9478 1120-009X |
| Popis: | Considering the clinical importance of biofilm in medical devices and chronic infections, this study aimed to investigate the action of polymyxin B on Klebsiella pneumoniae (K. pneumoniae) biofilm. The experiments were performed using a biofilm formation assay and the interaction of polysorbate 80 was explored. Both inhibition of biofilm formation and reduction of pre-formed biofilm occurred in a concentration-dependent manner with inhibition as high as 56 and 64%, and reduction of pre-formed biofilm as high as 70 and 66%, with and without polysorbate, respectively. The addition of polysorbate enhances the biofilm reduction, but more studies are needed to elucidate this mechanism. Our findings reveal, for the first time, polymyxin B as a potential agent for the treatment of K. pneumoniae biofilm, a current challenge for clinical practice. |
| Databáze: | OpenAIRE |
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