Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells

Autor: Koshi Kawakami, Koji Adachi, Tsutomu Takahashi, Takaaki Miyake, Yoshio Honma, Junji Suzumiya
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Cancer Research
Cell
Retinoic acid
Pharmacology
Arsenicals
growth inhibition
Mice
chemistry.chemical_compound
0302 clinical medicine
Arsenic Trioxide
Leukemia
Promyelocytic
Acute
Differentiation therapy
Medicine
Anthracyclines
Arsenic trioxide
Extracellular Signal-Regulated MAP Kinases
skin and connective tissue diseases
Mice
Inbred BALB C
CD11b Antigen
tamoxifen
Gene Expression Regulation
Leukemic
Myeloid leukemia
Cell Differentiation
Oxides
differentiation
Middle Aged
all-trans retinoic acid
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Cell Division
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Acute promyelocytic leukemia
Antineoplastic Agents
Hormonal
Cell Survival
Bone Marrow Cells
HL-60 Cells
Tretinoin
03 medical and health sciences
Cell Line
Tumor
acute promyelocytic leukemia cells
Animals
Humans
neoplasms
Cell Proliferation
Oncogene
business.industry
organic chemicals
medicine.disease
biological factors
030104 developmental biology
chemistry
business
Tamoxifen
Zdroj: INTERNATIONAL JOURNAL OF ONCOLOGY. 48(3):1095-1102
ISSN: 1019-6439
Popis: All-trans retinoic acid (ATRA) is valuable in differentiation therapy for acute promyelocytic leukemia (APL). However, ATRA has had limited success as a single agent, due to the development of resistance. We found that tamoxifen effectively enhanced the differentiation-inducing effect of ATRA. Tamoxifen alone inhibited the proliferation of myeloid leukemia cell lines while only slightly increasing morphologic differentiation. Tamoxifen effectively enhanced the growth-inhibiting actions of various differentiation-inducing agents. ATRA in the presence of tamoxifen increased NBT reduction and the expression of CD11b in HL-60 cells more effectively than ATRA alone. Tamoxifen also enhanced the differentiation induced by the other inducers tested. ATRA induced the differentiation of APL cell lines NB4 and HT93 and APL cells in primary culture, and this differentiation was also enhanced by tamoxifen. Tamoxifen is one of the most widely used drugs for the treatment of cancer and has few side effects. The combination of ATRA and tamoxifen might be considered for the treatment of APL patients in whom it can be difficult to apply arsenic trioxide or anthracyclines.
Databáze: OpenAIRE
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